Precisely targeting the interface between
innate and adaptive immunity.

Peter Cresswell, Ph.D.

Dr. Cresswell is Professor of Immunobiology, Cell Biology and Dermatology at Yale University School of Medicine.  He is also an investigator of the Howard Hughes Medical Institute.  He received his B.S. degree in chemistry, his M.S. degree in microbiology from the University of Newcastle Upon Tyne, U.K., and his Ph.D. degree in biochemistry and immunology from London University. His postdoctoral training was completed at Harvard University with Jack Strominger. Before assuming his position at Yale, Dr. Cresswell was Chief of the Division of Immunology at Duke University Medical Center. He is a Fellow of the Royal Society, U.K., and a member of the National Academy of Sciences.

Research summary: Peter Cresswell is interested in the functions of Major Histocompatibility Complex (MHC) molecules and CD1 molecules, which, respectively, bind peptides from foreign antigens and lipids, to form complexes recognized by T lymphocytes during immune responses. The mechanisms governing formation of MHC-peptide complexes are collectively known as antigen processing. Also of interest are the actions of a variety of proteins, induced by interferons that play a role in immunity to infection.